September 30, 2010

Krista's Journal: When Nature's Tools Provide the Answers

October 29, 2009

I've wondered for years how we could contribute some perspective to the moral consternation that stem cell research stirred in recent years. As with so many other real and important questions raised by medical advances, I have been unconvinced by the blunt either/or choice that culture-war debates seemed to present: defining stem cell research as either a slippery slope to killing babies or a straight path to curing a host of dreadful diseases. Efforts to humanize the issue with real-life examples — seeming to present a stark choice between condemning Michael J. Fox to death by Parkinson's, for example, or finding an immediate way to save him — can misrepresent both the promise of this science and the moral concerns it raises. Hearing Doris Taylor speak a few months ago was a revelation. I knew I had found our way in to this topic. When it comes to stem cells — as to everything else in life, it turns out — the truth is complicated. And much of the story of stem cells — the big picture that arguments have obscured — falls outside the realm of the most passionately contested issues. From Doris Taylor I come to understand, for the first time, that the existence and function of stem cells is one of those discoveries, not unlike DNA, that will fundamentally change the way we think about the human body. I learn that there are billions of stem cells throughout my 48-year-old body, and as I write they are repairing my organs and tissues as they have done all of my life — albeit less vigorously at 48 than at 8 because of the passage of time and the stresses that life has imposed, and that I have imposed on my body. The newness and rapidly emerging nature of our knowledge about stem cells has contributed to incomplete premises and an understandable measure of fear. Doris Taylor has spent time in conversation with people in churches these past years as well. She has come away with a conviction that, if the medical community and journalists had used different vocabulary to discuss stem cells at the outset, some of the most heated debates might have been avoided. She has often encountered the false impression that the stem cell lines used for research came from aborted fetuses. In fact, as she says, "fetal cells" are too old for the work she does. And the "embryonic cells" she uses have all come from eggs fertilized by way of in vitro fertilization (IVF) that would otherwise be destroyed. This insight, of course, does not address moral quandaries over embryos and IVF technology. But much of the research Doris Taylor and others are doing might one day circumvent all of these issues. If she could build me a heart by way of the process she and her colleagues are refining in the University of Minnesota Center for Cardiovascular Repair, she would use my heart stem cells to do so. Seeing the untold story of stem cells beyond the lightning rod, moral issues clears my vision to see unexpected spiritual implications of this work. The genius of Doris Taylor's work is in its simplicity — in realizing that there was no need to "build" a heart from scratch. Instead, she works with a dead heart, extracted from a cadaver — nature's cardiac "scaffolding," as she thinks of it. She washes the lifeless heart, cleans it, and injects the decellularized scaffold with cells that know how to colonize it — and begin to beat and live again. Doris Taylor echoes one of my favorite themes: beauty is essential to life itself — beauty as a core moral value — as she describes the architectural perfection of nature that she honors and works with. In an exhilarating "field trip" to her lab, which you can watch on our Web site, I was able to hold the translucent heart of a pig in my hand and see its exquisite intricacy — at once delicate and muscular — for myself. Approaching the mechanics of life at this level inevitably raises questions about life's mystery. Doris Taylor says she is passionate about "regenerating heart on a lot of different levels." And as she considers how new knowledge about stem cells might one day change the way we think about health across the life span — facing aging, for example, or cancer — she is studying how spiritual technologies like prayer and meditation might support that. She describes a very simple test she did on the Buddhist spiritual teacher Matthieu Ricard, who will be my guest on this program in two weeks. She measured a vast increase in stem cells in his blood after just 15 minutes of meditation. All of this said, the fascinating science of stem cell research still comes with a world of real and complex moral uncertainties. We hope this conversation with Doris Taylor might broaden existing conversations and inform fresh thinking on the moral and ethical questions her science touches. Let us hear your thoughts — either as they're sparked by this conversation or through your own experiences and knowledge.

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[video, 4:17] From my visit to Doris Taylor's lab, you can see elaborate architectural glass bulbs with tubes feeding suspended rodent hearts — one lifeless with old cells; another one stage farther, a pale "scaffold" ready for stem cells to be injected; and finally a regenerated heart pink, pumping, alive and beating on its own. Also, hear the story of the man with a heart disease that told Taylor she is "building hope."

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Taylor is the director of the Center for Cardiovascular Repair at the University of Minnesota in Minneapolis.

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