The Brazilian lyricist Paulo Coelho is best known for his book, The Alchemist — which has been on the New York Times bestseller list for over 400 weeks. His fable-like stories turn life, love, writing, and reading into pilgrimage. In a rare conversation, we meet the man behind the writings and explore what he’s touched in modern people.

Yoga has infiltrated law schools and strip malls, churches and hospitals. This 5,000-year-old spiritual technology is converging with 21st-century medical science and with many religious and philosophical perspectives. Seane Corn takes us inside the practicalities and power of yoga. She describes how it helps her face the darkness in herself and the world, and how she’s come to see yoga as a form of body prayer.

What happens when you bring together science and poetry on something like color or light? Arthur Zajonc is a physicist and contemplative. And he says we can all investigate life as vigorously from the inside as from the outside.

You might call Tami Simon a spiritual entrepreneur. She’s built a successful multimedia publishing company with a mission to disseminate “spiritual wisdom” by diverse teachers and thinkers like Pema Chödrön and Eckhart Tolle, Daniel Goleman and Brené Brown. She offers compelling lessons on joining inner life with life in the workplace — and advice on spiritual practice with a mobile device.

Esoteric teachings on reincarnation and consciousness; simple teachings on compassion and ethics. Geshe Thupten Jinpa is a man who finishes the Dalai Lama’s English sentences. Meet this philosopher and former monk, now a husband and father of two daughters, and hear what happens when the ancient tradition embodied in the Dalai Lama meets science and life.

Jon Kabat-Zinn has learned, through science and experience, about mindfulness as a way of life. This is wisdom with immediate relevance to the ordinary and extreme stresses of our time — from economic peril, to parenting, to life in a digital age.

Americans are religious and non-religious, devout and irreverent. But in astonishing numbers, across that spectrum, most of us say that we pray. We explore the subject of prayer, how it sounds, and what it means in three different traditions and lives.

One of today’s most influential spiritual teachers shares his youthful experience of depression and despair — suffering that led him to his own spiritual breakthrough, and ultimately, freedom and peace of mind. He also explicates his view of what he calls “the pain body” — the accumulated emotional pain that may influence us and our relationships in negative ways. And Tolle talks about spirit and God, and what those concepts mean to him.

A few years ago, journalist Pankaj Mishra pursued the social relevance of the Buddha’s thought across India and Europe, Afghanistan and America. He emerged with a startling critique of Western political economy that is even more resonant today as he pursued the social relevance of the Buddha’s core questions: Do desiring and acquiring make us happy? Does large-scale political change really address human suffering?

The American experience of stress has spawned a multi-billion dollar self-help industry. Wary of this, Esther Sternberg says that, until recently, modern science did not have the tools or the inclination to take emotional stress seriously. She shares fascinating new scientific insight into the molecular level of the mind-body connection.

In recent years, the practices of prayer have been evolving for many religious traditions. Even western medicine is looking at prayer as it expands its concept of healing. In this program, we consult several people from a variety of practices about the role of prayer in their lives.