The wise and lyrical writer Adam Gopnik muses on the ironies of spiritual life in a secular age through the lens of his many fascinations — from parenting, to the arts, to Darwin. He touches on all these things in a conversation inspired by his foreword to The Good Book, in which novelists, essayists, and activists who are not known as religious thinkers write about their favorite biblical passages. Our ancestors acknowledged doubt while practicing faith, he says; we moderns are drawn to faith while practicing doubt.

No challenge before us is more important — and more potentially life-giving — than that we come to see and know our fellow citizens, our neighbors, who have become strangers. Journalist Anand Giridharadas and Whitney Kimball Coe of the Rural Assembly have two very different histories and places in our life together. But they are both stitching relationship across the ruptures that have made politics thin veneers over human dramas of power and frailty, fear and hope. We spoke at the Obama Foundation’s inaugural summit in Chicago.

The new field of epigenetics sees that genes can be turned on and off and expressed differently through changes in environment and behavior. Rachel Yehuda is a pioneer in understanding how the effects of stress and trauma can transmit biologically, beyond cataclysmic events, to the next generation. She has studied the children of Holocaust survivors and of pregnant women who survived the 9/11 attacks. But her science is a form of power for flourishing beyond the traumas large and small that mark each of our lives and those of our families and communities.

Her unconventional studies have long suggested what neuroscience is now revealing: Our experiences are formed by the words and ideas we attach to them. Naming something play rather than work — or exercise rather than labor — can mean the difference between delight and drudgery, fatigue or weight loss. What makes a vacation a vacation is not only a change of scenery, but the fact that we let go of the mindless everyday illusion that we are in control. Ellen Langer says mindfulness is achievable without meditation or yoga. She defines it as “the simple act of actively noticing things.”

“When it comes to moral judgments, we think we are scientists discovering the truth, but actually we are lawyers arguing for positions we arrived at by other means.” The surprising psychology behind morality is at the heart of social psychologist Jonathan Haidt’s research. He explains “liberal” and “conservative” not narrowly or necessarily as political affiliations, but as personality types — ways of moving through the world. His self-described “conservative-hating, religion-hating, secular liberal instincts” have been challenged by his own studies.

It’s easy to despair at all the bad news and horrific pictures that come at us daily. But Roshi Joan Halifax says this is a form of empathy that works against us. There’s such a thing as pathological altruism. This zen abbot and medical anthropologist has nourishing wisdom as we face suffering in the world.

“When it comes to the world around us,” Lisa Randall has written, “is there any choice but to explore?” As one of the most influential theoretical physicists working today, she’s interested in the interconnectedness between fields that have previously operated more autonomously: astronomy, biology, and paleontology. She’s pursuing a theory that “dark matter” might have created the cosmic event that led to the extinction of the dinosaurs — and hence humanity’s rise as a species. We learn what she’s discovering, as well as the human questions and takeaways her work throws into relief.

“In a free society, some are guilty, but all are responsible.” A mystic, a 20th-century religious intellectual, a social change agent, Rabbi Abraham Joshua Heschel marched alongside Martin Luther King, Jr., famously saying afterwards that he felt his legs were praying. Heschel’s poetic theological writings are still read and widely studied today. His faith was as much about “radical amazement” as it was about certainty. And he embodied the passionate social engagement of the prophets, drawing on wisdom at once provocative and nourishing.

“From the bottom will the genius come that makes our ability to live with each other possible. I believe that with all my heart.” These are the words of the Pulitzer Prize-winning Dominican-American writer Junot Díaz. His hope is fiercely reality-based, a product of centuries lodged in his body of African-Caribbean suffering, survival, and genius.

Steeped in the cutting edge of research around the social lives of networked teens, danah boyd demystifies technology while being wise about the changes it’s making to life and relationship. She has intriguing advice on the technologically-fueled generation gaps of our age — that our children’s immersion in social media may offer a kind of respite from their over-structured, overscheduled analog lives. And that cyber-bullying is an online reflection of the offline world, and blaming technology is missing the point.

A French-born Tibetan Buddhist monk and a central figure in the Dalai Lama’s dialogue with scientists, Matthieu Ricard was dubbed “The Happiest Man in the World” after his brain was imaged. But he resists this label. In his writing and in his life, he explores happiness not as pleasurable feeling but as a way of being that gives you the resources to deal with the ups and downs of life and that encompasses many emotional states, including sadness. We take in Matthieu Ricard’s practical teachings for cultivating inner strength, joy, and direction.

We explore a topic our listeners have called out as a passionate force and a connector across all kinds of boundaries in American culture: running. Not just as exercise, or as a merely physical pursuit, but running as a source of bonding between parents and children and friends; running as an interplay between competition and contemplation; running and body image and survival and healing.

Humor lifts us up but it also underscores what’s already great; it connects us with others and also brings us home to ourselves. And like everything meaningful, it’s complex and nuanced — it can be fortifying or damaging, depending on how we wield it. But as a tool for survival, humor is elemental. We explore this idea with a rabbi who started out in drag, comedians, an NPR host, writers of sci-fi/fantasy, social commentary, and the TV show Veep.