“A dysfunctional family is any family with more than one person in it.” Mary Karr has a captivating ability to give voice to what is funny in life’s most heartbreaking moments. She is beloved for her salty memoirs in which she traces her harrowing childhood in southeast Texas — with a mother who once tried to kill her with a butcher’s knife and her own adult struggles with alcoholism and breakdown. Mary Karr embodies this wryness and wildness in her lesser-known spiritual practice as a devout Catholic — an unexpected move she made in mid-life.

A French-born Tibetan Buddhist monk and a central figure in the Dalai Lama’s dialogue with scientists, Matthieu Ricard was dubbed “The Happiest Man in the World” after his brain was imaged. But he resists this label. In his writing and in his life, he explores happiness not as pleasurable feeling but as a way of being that gives you the resources to deal with the ups and downs of life and that encompasses many emotional states, including sadness. We take in Matthieu Ricard’s practical teachings for cultivating inner strength, joy, and direction.

Humor lifts us up but it also underscores what’s already great; it connects us with others and also brings us home to ourselves. And like everything meaningful, it’s complex and nuanced — it can be fortifying or damaging, depending on how we wield it. But as a tool for survival, humor is elemental. We explore this idea with a rabbi who started out in drag, comedians, an NPR host, writers of sci-fi/fantasy, social commentary, and the TV show Veep.