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Anthropologist Helen Fisher explores the biological workings of our intimate passions, the brew of chemicals, hormones, and neurotransmitters that make the thrilling and sometimes treacherous realms of love and sex. In the research she does for match.com and her TED Talks that have been viewed by millions of people, she wields science as an entertaining, if sobering, lens on what feel like the most meaningful encounters of our lives. In this deeply personal conversation, she shows how it is possible to take on this knowledge as a form of wisdom and power.

New research reveals that trauma experienced in childhood has longterm damaging effects on quality of life and lifespan. But the same research shows that adults play a critical role in helping children overcome this damage.

The new field of epigenetics sees that genes can be turned on and off and expressed differently through changes in environment and behavior. Rachel Yehuda is a pioneer in understanding how the effects of stress and trauma can transmit biologically, beyond cataclysmic events, to the next generation. She has studied the children of Holocaust survivors and of pregnant women who survived the 9/11 attacks. But her science is a form of power for flourishing beyond the traumas large and small that mark each of our lives and those of our families and communities.

We explore a topic our listeners have called out as a passionate force and a connector across all kinds of boundaries in American culture: running. Not just as exercise, or as a merely physical pursuit, but running as a source of bonding between parents and children and friends; running as an interplay between competition and contemplation; running and body image and survival and healing.

Black Lives Matter co-founder and artist Patrisse Cullors presents a luminous vision of the spiritual core of Black Lives Matter and a resilient world in the making. She joins Dr. Robert Ross, a physician and philanthropist on the cutting edge of learning how trauma can be healed in bodies and communities. A cross-generational reflection on evolving social change.

Sheryl Sandberg is synonymous with Facebook and Silicon Valley success, and she’s the voice of Lean In. She joins us, frank and vulnerable, together with the psychologist Adam Grant. His friendship — and his research on resilience — helped her survive the shocking death of her husband while on vacation. They share what they’ve learned about planting deep resilience in ourselves and our children, and even reclaiming joy. There is so much learning here on facing the unimaginable when it arrives in our lives and being more practically caring towards the losses woven into lives all around us.

Kevin Kling is part funny guy, part poet and playwright, part wise man. A treasured figure on the national storytelling circuit, his voice inhabits an unusual space — where a homegrown Minnesota wit meets Dante and Shakespeare. Born with a disabled left arm, he lost the use of his right one after a motorcycle accident nearly killed him. He shares his special angle on life’s humor and its ruptures — and why we turn loss into story.

“Let death be what takes us,” Dr. BJ Miller has written, “not a lack of imagination.” As a palliative care physician, he brings a design sensibility to the matter of living until we die. And he’s largely redesigned his sense of own physical presence after an accident at college left him without both of his legs and part of one arm. He offers a transformative reframing on our imperfect bodies, the ways we move through the world, and all that we don’t control.

A transformation of medicine is underway, a transition from a science of treating disease to a science of health. Mark Hyman is a family physician and a pioneer in the new discipline of functional medicine. James Gordon is an expert in using mind-body medicine to heal depression, anxiety, and psychological trauma. Penny George became a philanthropist of integrative medicine after she experienced cancer in mid-life. Before a live audience at the University of Minnesota, they discuss the challenge and promise of aligning medicine with a 21st century understanding of human wholeness.

Eve Ensler has helped women all over the world tell the stories of their lives through the stories of their bodies. Her play, “The Vagina Monologues,” has become a global force in the face of violence against women and girls. But she herself also had a violent childhood. And it turns out that she, like so many Western women, was obsessed by her body and yet not inhabiting it without even knowing she wasn’t inhabiting her body — until she got cancer.

Yoga has infiltrated law schools and strip malls, churches and hospitals. This 5,000-year-old spiritual technology is converging with 21st-century medical science and with many religious and philosophical perspectives. Seane Corn takes us inside the practicalities and power of yoga. She describes how it helps her face the darkness in herself and the world, and how she’s come to see yoga as a form of body prayer.

Who knew that we learn empathy, trust, irony, and problem solving through play — something the dictionary defines as “pleasurable and apparently purposeless activity.” Dr. Stuart Brown suggests that the rough-and-tumble play of children actually prevents violent behavior, and that play can grow human talents and character across a lifetime. Play, as he studies it, is an indispensable part of being human.

Dr. Sherwin Nuland died this week at the age of 83. He became well-known for his first book, How We Die, which won the National Book Award. For him, pondering death was a way of wondering at life — and the infinite variety of processes that maintain human life moment to moment. He reflects on the meaning of life by way of scrupulous and elegant detail about human physiology.