“Let death be what takes us,” Dr. BJ Miller has written, “not a lack of imagination.” As a palliative care physician, he brings a design sensibility to the matter of living until we die. And he’s largely redesigned his sense of own physical presence after an accident at college left him without both of his legs and part of one arm. He offers a transformative reframing on our imperfect bodies, the ways we move through the world, and all that we don’t control.

Something of a celebrity in Quaker circles, Carrie Newcomer is best known for her story-songs that get at the raw and redemptive edges of human reality. This week, a musical conversation with the Indiana-based and born folk singer-songwriter who’s been called a “prairie mystic.” She writes and sings about the grittiness of hope and the ease of cynicism.

The Irish poet and New Yorker poetry editor Paul Muldoon has won the Pulitzer Prize, written for other media from radio to song, and plays in a rock band. He visited us for a magical day at the On Being studios on Loring Park in Minneapolis, including a dinner salon and reading from his work.

A transformation of medicine is underway, a transition from a science of treating disease to a science of health. Mark Hyman is a family physician and a pioneer in the new discipline of functional medicine. James Gordon is an expert in using mind-body medicine to heal depression, anxiety, and psychological trauma. Penny George became a philanthropist of integrative medicine after she experienced cancer in mid-life. Before a live audience at the University of Minnesota, they discuss the challenge and promise of aligning medicine with a 21st century understanding of human wholeness.

The philosopher Simone Weil defined prayer as “absolutely unmixed attention.” The artist Ann Hamilton embodies this notion in her sweeping works of art that bring all the senses together. She uses her hands to create installations that are both visually astounding and surprisingly intimate, and meet a longing many of us share, as she puts it, to be alone together.

The organizational psychologist Adam Grant, who many know from his New York Times columns, describes three orientations of which we are all capable: the givers, the takers, and the matchers. These influence whether organizations are joyful or toxic for human beings. His studies are dispelling a conventional wisdom that selfish takers are the most likely to succeed professionally. And he is wise about practicing generosity in organizational life — what he calls making “microloans of our knowledge, our skills, our connections to other people” — in a way that is transformative for others, ourselves, and our places of work.

When we talk about the relationship between colleges and the world, we tend to focus on economics. But what is the place of institutions of higher education in the communities they inhabit? How can and should they nurture students as citizens and leaders for the emerging 21st century world? Two visionary college presidents of two very different institutions take up these questions with Krista at the American Council on Education’s 97th Annual Meeting.

The High Holy Days create an annual ritual of repentance, both individual and collective. Louis Newman, who has explored repentance as an ethicist and a person in recovery, opens this up as a refreshing practice for every life, even beyond the lifetime of those to whom we would make amends.

Few features of humanity are more fascinating than creativity; and few fields are more dynamic now than neuroscience. Rex Jung is a neuropsychologist who puts the two together. He’s working on a cutting edge of science, exploring the differences and interplay between intelligence and creativity. He and his colleagues unsettle long-held beliefs about who is creative and who is not. And they’re seeing practical, often common-sense connections between creativity and family life, aging, and purpose.

Rami Nashashibi uses graffiti, calligraphy, and hip-hop in his work as a healing force on the South Side of Chicago. A Palestinian-American, he started his activism with at-risk urban Muslim families, especially youth, while he was still a college student. Now he’s the leader of a globally-emulated project converging religious virtues, the arts, and social action. And he is a fascinating face of a Muslim-American dream flourishing against the odds in post-9/11 America.

She became a national figure as the face of the “Nuns on the Bus.” Sr. Simone Campbell is a lawyer, lobbyist, poet, and Zen contemplative working on issues such as “mending the wealth gap,” “enacting a living wage,” and “crafting a faithful budget that benefits the 100%.” She is a helpful voice for longings so many of us share, across differences, about how to engage with the well-being of our neighbors in this complicated age.

It is a story of our time — the new landscape of living longer, and of dying more slowly too. Jane Gross has explored this as a daughter and as a journalist, and as creator of the New York Times’ “New Old Age” blog. She has grounded advice and practical wisdom about caring for our loved ones and ourselves on the far shore of aging.

What would it take to make our national encounter with gay marriage redemptive rather than divisive? David Blankenhorn and Jonathan Rauch came to the gay marriage debate from very different directions — but with a shared concern about the institution of marriage. Now, they’re pursuing a different way for all of us to grapple with the future of marriage, redefined. They model a fresh way forward as the subject of same-sex marriage is before the Supreme Court.

From the moment of his diagnosis with ALS, Bruce Kramer began writing — openly, deeply, and spiritually — about his struggle, as he puts it, to live while dying. He died on March 23, 2015, while we were in production on this show. His words hold abiding joy and beauty, and reveal an unexpected view opened by this disease.

Alzheimer’s disease has been described as “the great unlearning.” But what does it reveal about the nature of human identity? What remains when memory unravels? Alan Dienstag is a psychologist who has led support groups with early Alzheimer’s patients, as well as a writing group he co-designed with the novelist Don DeLillo. He’s experienced the early stages of Alzheimer’s as a time for giving memories away rather than losing them.